The Importance Of Neural Stem Cells - 984 Words

My combined interest in discovery and earning a Ph.D. eventually led to my first research experience through the NeuroSURP program at Rutgers University. There, I became a part of the laboratory of Dr. Emanuel DiCicco-Bloom and worked on a project titled,† Neural Stem Cells from Autism Spectrum Disorder (ASD) Patient Exhibit Abnormal Neurite Outgrowth.† Autism Spectrum Disorder (ASD) is a highly heritable neurodevelopmental disorder of impaired communication skills and repetitive restrictive behavior. Studies have concluded that genes implicated in ASD diagnoses converge to regulate signaling pathways for neurodevelopmental processes like migration, proliferation, and differentiation. Basic fibroblast growth factor (FGF-2) has been proven†¦show more content†¦With continued experimentation to validate or expand upon these hypotheses, we may be able to explain postulate how this dysfunction leads to ASD phenotypes, and how those developmental disorders may be pre vented. I continued my passion for research in the neuroscience laboratory of Dr. Raimi Quiton in the Psychology Department of the Univeristy of Maryland, Baltimore County UMBC . Through this lab I had the opportunity to investigate the effect of biopsychosocial factors on human pain modulation. Implications of this study stretch to health care and treatment for individuals within diverse groups. With the right application, it can also help to decrease the stereotypes imposed upon certain patient groups when given pain treatment. These outcomes, though far away at this point, have allowed me to be a part of an experience that speaks to my ambition of effecting social change through research. Despite this experience being a world away from the cell culture of the previous summer, I became HIPAA certified, ethics trained, and became trained for human pain testing. In addition to conducting thermal and pressurized pain experiments, I also managed projects within the lab, collected and analyze d data, planned experiments, and trained new research assistants. During extended periods when my mentor and principle investigator were away onShow MoreRelatedHuman Neural Stem Cell Tropism857 Words   |  4 PagesARTICLE TITLE: Human Neural Stem Cell Tropism to Metastatic Breast Cancer ESSAY TITLE: The Investigation of a therapeutic implication on metastatic breast cancer with a specialized human neural stem cell that is programed to secrete carboxylesterase combined with activated form of an ionotecan by targeting a specific tumor site and major cytokine involved in mediating susceptibility of neural stem cells to breast cancer cells. SCIENTIFIC SUMMARY: Metastatic Breast Cancer is characterized as aRead MoreThe Importance Of Neurogenins1402 Words   |  6 PagesNgn1, Ngn2, astrogliogenesis, neurogenesis, neural stem/progenitor cells (NSPCs), JAK-STAT. Abbreviations: NSPC: Neural stem/progenitor cells Ngn: Neurogenins bHLH: basic-Helix-Loop-Helix E- Embryonic day Introduction Neural stem/progenitor cells are the multipotent cells of the brain. They have two functions in the CNS: 1. Self renewal- NSPCs undergo symmetric division and give rise to two identical daughter cells. 2.Differentiation- NSPCs undergo asymmetricRead MoreEssay On Glioblastoma1349 Words   |  6 Pagescharacterization into defined transcription profiles such as classical, neural, pro-neural and mesenchymal types5. Additionally, the commonly occurring genetic aberrations of primary GB are amplifications/mutations of EGFR, PDGFRA, PTEN, and of secondary GB are IDH1, MDM2 and p536-11. Despite efforts to dissect tumor heterogeneity of this malignant tumor, till date this genomic profiling has proven to be insufficient to improve therapy 3. The cell of origin of GB tumors is still under debate, owing to its heterogeneityRead More Use of Fetal Tissue Research to Cure/Treat Neurological Disorder1012 Words   |  5 Pagesacting together directs behavior, it is very difficult to repair or tre at any disorders of the nervous system. Doctors are not just treating a single cell that can be replaced but an entire system with intertwining and unknown connections. Recent research involving transplanted fetal tissue has shown vast potential for hope in many areas of neural study. The basic idea is that the issue will replace or regrow tissue in damaged areas of the brain. Fetal tissue research was banned during the BushRead MoreStem Cells And The Human Body1170 Words   |  5 PagesStem cells are different to all other cells in the human body because they have unique abilities to divide repeatedly, make many copies of themselves or differentiate into specialised cells such as skin cells, immune cells or nerve cells. Stem cells are also described as unspecialised because they are not yet advanced to perform an exact function. However, each of them has the potential to develop into one of a number of different specialised cell types depending on the body’s needs at a particularRead MoreParkinson s Disease As A Medical Condition1437 Words   |  6 Pagesit would encourage others to study the disease. No such research was performed until f inally, sixty years after Parkinson’s essay was published, a French neurologist named Jean Charcot studied the disease and was the first to truly recognize the importance of Parkinson’s work. As a result, he named the disease after him. Much has been learned about the disease since then; however, much of it still remains a mystery. Researchers have learned that the symptoms for this disease are progressive, degenerativeRead MoreMechanisms of Neuronal Repair Following Nerve Damage2370 Words   |  10 Pagesperipheral nervous systems depend highly on the successful functionality of afferent and efferent neurons. Neurons are cells that have the ability to transmit sensory and motor messages throughout the body. These signals are promoted by electrically insulating myelin sheaths that surround the axons of neurons. These sheaths are produced by Schwann cells and other glial cells. When a neuron is damaged, a communicative circuit is compromised and essential signals ca nnot be transmitted throughoutRead MoreInvestigating The Outcome Pathways Regulated By Thyroid Hormone867 Words   |  4 Pageshormone (TH) and determine whether these differ significantly between species. Primary rat (neurospheres and dissociated cortical cultures) and human (neurospheres and neurons derived from induced pluripotent stem cells [iPSCs]) cultures will be used to determine which early (neural precursor cell [NPC] proliferation, migration and differentiation] and late (axonal and dendritic outgrowth, synaptogenesis, network formation) neurodevelopmental processes are most vulnerable to modulation by TH receptorRead MoreThe Debate Over Stem Cell Research1196 Words   |  5 Pagescontroversy over the topic of stem cell research. It seems to be that the main controversy when it comes to the topic of stem cell research is an ethical debate, and because of this it seems that the side opposing stem cell research always wins due to their use of pathos when it comes to their argument. I personally do not side with those against the idea of stem cell research because I believe that the pros outweigh the cons when you break it down this way. Stem cell research could be the gatewayRead MoreBranching Out With Stem Cells1400 Words   |  6 Pagesby Branching Out With Stem Cells Imagine a child, no more than six years old, with a failing liver. There is no way for that child to receive a functional liver because of the waiting list for organs. That child will almost certainly die waiting for that liver, and never get close to the top of the list. The main reason for this is quite simple: there are not nearly enough organs available for transplant to save the people that need them. Because the research of stem cells isn’t developed or funded